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. 1976 Oct:129:342-5.
doi: 10.1192/bjp.129.4.342.

Mianserin hydrochloride: a novel antidepressant

A Coppen, R Gupta, S Montgomery, K Ghose, J Bailey, B Burns, J J de Ridder

Mianserin hydrochloride: a novel antidepressant

A Coppen et al. Br J Psychiatry. 1976 Oct.

Abstract

The antidepressant activities of mianserin hydrochloride were investigated and compared with those of amitriptyline. The therapeutic efficacy of the two drugs appeared similar, but the incidence of side-effects was significantly higher with amitriptyline. Plasma levels of mianserin were determined during the trial and were not related to the therapeutic activity of the drug.

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