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Clinical Trial
. 1998 Sep;78(5):683-5.
doi: 10.1038/bjc.1998.560.

Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study

F A Shepherd  1 , M R Johnston, D Payne, R Burkes, J Deslauriers, Y Cormier, L D de Bedoya, J Ottaway, K James, B Zee
Affiliations
Free PMC article
Clinical Trial

Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study

F A Shepherd et al. Br J Cancer. 1998 Sep.
Free PMC article

Abstract

Thirty-one patients with stage IIIA (N2) non-small-cell lung cancer were randomized to receive radiotherapy alone or chemotherapy with cisplatin and vinblastine followed by surgery. Response rates to induction chemotherapy and radiotherapy were 50% and 53.3% respectively. Complete surgical resection was possible for 62.5% of patients. Median survival times were 16.2 and 18.7 months for radiotherapy alone and chemotherapy-surgery respectively (P = Ns), with no long-term improvement in survival seen with combined-modality treatment.

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