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Review
. 1998 Aug;6(8):323-7.
doi: 10.1016/s0966-842x(98)01317-1.

beta-Lactamases: protein evolution in real time

J Petrosino  1 , C Cantu 3rd, T Palzkill
Affiliations
Review

beta-Lactamases: protein evolution in real time

J Petrosino et al. Trends Microbiol. 1998 Aug.

Abstract

The evolution and spread of bacteria resistant to beta-lactam antibiotics has progressed at an alarming rate. Bacteria may acquire resistance to a given drug by mutation of pre-existing genes or by the acquisition of new genes from other bacteria. One ongoing example of these mechanisms is the evolution of new variants of the TEM and SHV beta-lactamases with altered substrate specificity.

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