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. 1998 Sep;51(3):742-7.
doi: 10.1212/wnl.51.3.742.

Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study

B G Weinshenker  1 , P Santrach, A S Bissonet, S K McDonnell, D Schaid, S B Moore, M Rodriguez
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Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study

B G Weinshenker et al. Neurology. 1998 Sep.

Abstract

Background: The major histocompatibility complex (MHC) has been consistently associated with susceptibility to MS and the course of several other human autoimmune diseases. A putative association between the course and severity of MS and the MHC remains controversial.

Methods: DR and DQ genotyping by either restriction fragment length polymorphism or sequence-specific PCR-based typing in 119 patients representing 73.4% of the population with MS evaluated in a cross-sectional disability survey and 100 healthy controls from Olmsted County, Minnesota.

Results: We found a positive association between MS susceptibility and the DR15-DQ6 and DR13-DQ7 haplotypes, and we found a negative association with the DR1-DQ5 haplotype. We found a trend to a positive association of primary progressive MS with DR4-DQ8 and DR1-DQ5 and an association of "bout onset" MS with DR17-DQ2. We did not find an association with disease severity, as defined by EDSS/duration.

Conclusion: Lack of consistency between different studies may be due to regional variation in MS and limitations of power but likely indicate a minor effect of MHC class II genes on the course and severity of MS.

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