Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Sep;51(3):753-8.
doi: 10.1212/wnl.51.3.753.

Increased release of interleukin-12p40 in MS: association with intracerebral inflammation

K Fassbender  1 , A Ragoschke, S Rossol, A Schwartz, O Mielke, A Paulig, M Hennerici
Affiliations

Increased release of interleukin-12p40 in MS: association with intracerebral inflammation

K Fassbender et al. Neurology. 1998 Sep.

Abstract

Objective: The p40 subunit of interleukin (IL)-12 was recently demonstrated in active lesions in MS. We tested whether the p40 subunit of IL-12 can also be detected in CSF and serum of patients with this disease and, if so, whether release is associated with inflammatory disease activity.

Results: This study demonstrates an increased (up to 1,000-fold) compartmentalized release of the p40 subunit but not of the heterodimer p70 in MS. Release of IL-12p40 correlated with classic markers of CNS inflammation (CSF cell counts, immunoglobulin G index) and was significantly increased in patients with gadolinium-enhancing plaques on MRI. Moreover, release of IL-12p40 was associated with CSF levels of myelin basic protein as a measure of myelin degradation.

Conclusion: These results suggest a role of IL-12p40 in the pathophysiology of MS.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources