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Review
. 1998 Sep 26;317(7162):875-80.
doi: 10.1136/bmj.317.7162.875.

When placebo controlled trials are essential and equivalence trials are inadequate

M R Tramèr  1 , D J Reynolds, R A Moore, H J McQuay
Affiliations
Review

When placebo controlled trials are essential and equivalence trials are inadequate

M R Tramèr et al. BMJ. .
No abstract available

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Figures

Figure 1
Figure 1
Data on included and excluded trials
Figure 2
Figure 2
Event rate scattergrams showing cumulative event rates up to 48 hours after surgery from (top) placebo and “no treatment” controlled trials and (bottom) active controlled trials (dotted line represents equality)
Figure 3
Figure 3
Potential shortcomings of active controlled trials
See this image and copyright information in PMC

Comment in

References

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    1. Markman M. When regulatory requirements conflict with ethical study design: the case of oral ondansetron. Cancer Invest. 1994;12:654–656. - PubMed

Publication types