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. 1998 Sep;61(9):1075-7.
doi: 10.1021/np980321c.

Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

G G Harrigan  1 , H Luesch, W Y Yoshida, R E Moore, D G Nagle, V J Paul, S L Mooberry, T H Corbett, F A Valeriote
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Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

G G Harrigan et al. J Nat Prod. 1998 Sep.

Abstract

A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.

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