doi: 10.1139/y76-088.
Differing estrogenic activities for the enantiomers of o, p'-DDT in immature female rats
- PMID: 974891
- DOI: 10.1139/y76-088
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Differing estrogenic activities for the enantiomers of o, p'-DDT in immature female rats
Can J Physiol Pharmacol.
1976 Aug.
Abstract
Female rats (20-21 days) were given single intraperitoneal injections of (+/-)-o,p'-DDT, (--)-o,p'-DDT, or (+)-o,p'-DDT. At 18 h their uteri were excised and the estrogen sensitive parameters, uterine wet weight, and uterine glycogen content were measured. For o,p'-DDT, the levo enantiomer is the more active estrogen in immature female rats. Optical resolutions of other racemic environmental xenobiotics may be important in the evaluation of their biological effects.
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