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. 1976 Aug;54(4):629-32.
doi: 10.1139/y76-088.

Differing estrogenic activities for the enantiomers of o, p'-DDT in immature female rats

W A McBlain, V Lewin

Differing estrogenic activities for the enantiomers of o, p'-DDT in immature female rats

W A McBlain et al. Can J Physiol Pharmacol. 1976 Aug.

Abstract

Female rats (20-21 days) were given single intraperitoneal injections of (+/-)-o,p'-DDT, (--)-o,p'-DDT, or (+)-o,p'-DDT. At 18 h their uteri were excised and the estrogen sensitive parameters, uterine wet weight, and uterine glycogen content were measured. For o,p'-DDT, the levo enantiomer is the more active estrogen in immature female rats. Optical resolutions of other racemic environmental xenobiotics may be important in the evaluation of their biological effects.

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