[Endothelial cells and leukocytes--significance of adhesion interactions]

Abstract

Interactions between endothelial cells, adherence of endothelial cells to the molecules of extracellular matrix, adhesion of leukocytes and platelets to the activated endothelial cell lining are mediated by adhesion molecules belonging into four families: immunoglobulins, integrins, selectins, and cadherins. Adhesion interactions mediate intercellular signaling. Soluble forms of adhesion molecules modulate adhesion interactions. The determination of soluble adhesion molecules in blood is used for indirect evaluation of function or dysfunction of endothelial cells. It is possible to modulate abnormal function of endothelial cells using monoclonal antibodies against adhesion molecules.