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Clinical Trial
. 1998;17(1):27-31.
doi: 10.1016/s0750-7658(97)80178-5.

[The good use of antibiotics in intensive care: results of a program for rationalization of prescriptions]

[Article in French]
I Mohammedi  1 , S Duperret, J M Védrinne, B Allaouchiche, B Bui-Xuan, P Boulétreau
Affiliations
Clinical Trial

[The good use of antibiotics in intensive care: results of a program for rationalization of prescriptions]

[Article in French]
I Mohammedi et al. Ann Fr Anesth Reanim. 1998.

Abstract

Objective: To assess the impact of an antibiotic prescribing programme in a intensive therapy unit.

Type of study: Prospective comparative study.

Methods: We compared antibiotic prescriptions and bacterial susceptibility to antimicrobial agents before and after introduction of a programme focusing on injection control and therapeutic indications.

Results: The introduction of the programme resulted in a major decrease in antibiotic administration. Moreover, the susceptibility of Pseudomonas aeruginosa to ticarcillin increased from 40 to 68%, and susceptibility of Staphylococcus aureus to methicillin increased from 55 to 73%.

Conclusions: Antibiotic control policies must be considered integral to any effort to decrease resistance and cost of therapy with antibiotics.

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