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Review
. 1998 Sep 29;95(20):11506-8.
doi: 10.1073/pnas.95.20.11506.

Native secondary structure formation in RNA may be a slave to tertiary folding

D Thirumalai  1
Affiliations
Review

Native secondary structure formation in RNA may be a slave to tertiary folding

D Thirumalai. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
(Upper) The structural rearrangements involved in the transition from the unfolded state to the folded conformation. The secondary structures of P5abc are adopted from ref. . The green circles represent the magnesium ions. For clarity of presentation only part of the magnesium ions in the core is shown. The possible nucleation regions are shown in blue. (Lower) A schematic sketch of the free energy profile and the associated ensemble of transition states is shown. The question marks indicate that the nature of the kinetic steps in the interconversion of the solution structure to the crystal structure under folding conditions are conjectural and require experimental validation. This figure was prepared by Oksana Klimov, and her assistance is greatly appreciated.
See this image and copyright information in PMC

Comment on

References

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