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. 1978 Aug;54(1):33-8.
doi: 10.1016/0165-1161(78)90132-2.

The use of a mutationally unstable X-chromosome in Drosophila melanogaster for mutagenicity testing

B Rasmuson, H Svahlin, A Rasmuson, I Montell, H Olofsson

The use of a mutationally unstable X-chromosome in Drosophila melanogaster for mutagenicity testing

B Rasmuson et al. Mutat Res. 1978 Aug.

Abstract

Somatic eye-colour mutations in an unstable genetic system, caused by a transposable element in the white locus of the X-chromosome in Drosophila melanogaster, is suggested as an assay system for mutagenicity testing. The system is evaluated by comparison with a corresponding system in a stable X-chromosome. Its sensitivity is confirmed with X-ray and EMS treatment, and it is found to be confined to the specific segment of the X-chromosome where the transposable element is localized.

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