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Clinical Trial
. 1998 Aug 28;253(1):5-8.
doi: 10.1016/s0304-3940(98)00603-x.

Entropy maps characterize drug effects on brain dynamics in Alzheimer's disease

L Pezard  1 , J Martinerie, F J Varela, F Bouchet, D Guez, C Derouesné, B Renault
Affiliations
Clinical Trial

Entropy maps characterize drug effects on brain dynamics in Alzheimer's disease

L Pezard et al. Neurosci Lett. .

Erratum in

  • Neurosci Lett 1998 Sep 4;253(2):142

Abstract

Non-linear quantifiers of brain electrical dynamics (entropy maps computed from the degradation of temporal forecasting of EEG signals) were studied in relation to drug treatment of Alzheimer's disease. A placebo condition was compared to three drug doses (50, 100 and 200 mg). A significant general effect of the drug was found when compared to placebo and specific contrasts between placebo and each of the three drug doses only reveal a significant entropy increase for the highest dose. These effects were localized bilaterally in fronto-temporal areas and support changes in the dynamics of the cerebral structures involved in memory processes.

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