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. 1998 Aug;52(2):179-82.
doi: 10.1111/j.1399-0039.1998.tb02282.x.

HLA-DP-associated susceptibility to the optico-spinal form of multiple sclerosis in the Japanese

H Ito  1 , K Yamasaki, Y Kawano, I Horiuchi, C Yun, Y Nishimura, J Kira
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HLA-DP-associated susceptibility to the optico-spinal form of multiple sclerosis in the Japanese

H Ito et al. Tissue Antigens. 1998 Aug.

Abstract

We studied polymorphism of the HLA-DP gene in 46 patients with optico-spinal form (Asian type) multiple sclerosis (MS) showing recurrent opticomyelitis and 46 patients with Western type MS with disseminated central nervous system involvement. We previously reported a significant association between an HLA-DRB1 *1501-DRB5*0101 haplotype and susceptibility to Western type but not Asian type MS. In the present study, we found that the frequencies of DPA1 *0202 and DPB1 *0501 alleles were significantly increased in patients with Asian type MS, as compared with findings in 92 healthy control subjects (91.3% vs 65.2%, P(corr)<0.05 and 89.1% vs 63.0%, P(corr)<0.05 respectively), but not in Western type MS. Our data provide further evidence that Asian and Western type MS are distinct regarding the immunogenetic background.

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