Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1998 Oct;42(10):2747-8.
doi: 10.1128/AAC.42.10.2747.

In vitro susceptibility of Coxiella burnetii to trovafloxacin in comparison with susceptibilities to pefloxacin, ciprofloxacin, ofloxacin, doxycycline, and clarithromycin

A Gikas  1 , I Spyridaki, A Psaroulaki, D Kofterithis, Y Tselentis
Affiliations
Comparative Study

In vitro susceptibility of Coxiella burnetii to trovafloxacin in comparison with susceptibilities to pefloxacin, ciprofloxacin, ofloxacin, doxycycline, and clarithromycin

A Gikas et al. Antimicrob Agents Chemother. 1998 Oct.

Abstract

The antibiotic susceptibilities of eight Greek isolates of Coxiella burnetii to trovafloxacin were determined by the shell vial assay. MICs of trovafloxacin and ofloxacin ranged from 1 to 2 microg/ml, those of pefloxacin ranged from 1 to 4 microg/ml, those of ciprofloxacin ranged from 4 to 8 microg/ml, those of doxycycline ranged from 1 to 2 microg/ml, and those of clarithromycin ranged from 2 to 4 microg/ml. Trovafloxacin exhibited no activity against C. burnetii at 4 microg/ml.

PubMed Disclaimer

References

    1. Jabarit-Aldighieri N, Torres H, Raoult D. Susceptibility of Rickettsia conori, R. rickettsii, and Coxiella burnetii to PD 127,391, PD 131,628, pefloxacin, ofloxacin, and ciprofloxacin. Antimicrob Agents Chemother. 1992;36:2529–2532. - PMC - PubMed
    1. Keren G, Keysary A, Goldwasser R, Rubinstein E. The inhibitory effect of fluoroquinolones on Coxiella burnetii growth in in-vitro systems. J Antimicrob Chemother. 1994;33:1253–1255. - PubMed
    1. Levy P Y, Drancourt M, Etienne J, Auvergnat J C, Beytout J, Sainty J M, Goldstein F, Raoult D. Comparison of different antibiotic regimens for therapy of 32 cases of Q fever endocarditis. Antimicrob Agents Chemother. 1991;35:533–537. - PMC - PubMed
    1. Maurin M, Raoult D. Optimum treatment of intracellular infection. Drugs. 1996;52:45–49. - PubMed
    1. Maurin M, Benoliel A M, Bongrand P, Raoult D. Phagolysosomal alkalinization and the bactericidal effect of antibiotics: the Coxiella burnetii paradigm. J Infect Dis. 1992;166:1097–1102. - PubMed

Publication types

MeSH terms

LinkOut - more resources