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Clinical Trial
. 1998 Sep;179(3 Pt 1):640-3.
doi: 10.1016/s0002-9378(98)70057-2.

Treating ectopic pregnancy with the combination of mifepristone and methotrexate: a phase II nonrandomized study

M Perdu  1 , E Camus, P Rozenberg, F Goffinet, C Chastang, H J Philippe, I Nisand
Affiliations
Clinical Trial

Treating ectopic pregnancy with the combination of mifepristone and methotrexate: a phase II nonrandomized study

M Perdu et al. Am J Obstet Gynecol. 1998 Sep.

Abstract

Objective: Our goal was to compare the use of a combination of methotrexate and mifepristone with methotrexate alone in the medical management of ectopic pregnancy.

Study design: This was a preliminary nonrandomized phase II study. All patients with progressing ectopic pregnancy meeting criteria for medical management were included. Treatment consisted of 50 mg/m2 of methotrexate injected intramuscularly and 600 mg of mifepristone, administered orally, compared with a previous group who received only 50 mg/m2 of methotrexate injected intramuscularly.

Results: Of the 30 patients treated with the combination, there was only 1 failure, whereas medical treatment had failed for 11 of 42 patients treated with methotrexate alone.

Conclusions: The combination of mifepristone and methotrexate decreased the risk of failure in medical treatment of ectopic pregnancy.

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