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Review
. 1998;192(3):437-44.

[Anthrax toxins]

[Article in French]
F Brossier  1 , C Guidi-Rontani, M Mock
Affiliations
  • PMID: 9759382
Review

[Anthrax toxins]

[Article in French]
F Brossier et al. C R Seances Soc Biol Fil. 1998.

Abstract

Bacillus anthracis, a Gram positive bacterium, is the causative agent of anthrax. This organism is capsulogen and toxinogenic. It secretes two toxins which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF). The lethal toxin (PA + LF) provokes a subite death in animals, the edema toxin (PA + EF) induces edema. The edema and the lethal factors are internalised into the target cells via the protective antigen. EF and LF exert an adenylate cyclase and a metalloprotease activity respectively. The structure-function relationship of these three proteins were defined using in vitro and in vivo approaches.

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