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. 1976 Jun 30;56(1):1-13.
doi: 10.1007/BF00293724.

Study of mitomycin C-induced chromosomal exchange

K M Huttner, F H Ruddle

Study of mitomycin C-induced chromosomal exchange

K M Huttner et al. Chromosoma. .

Abstract

Mitomycin C-induced sister chromatic exchange and quadriradial formation were studied in chromosomes from Muntiacus muntjac fibroblasts and A9, a transformed mouse cell line. We present the first direct cytological evidence for the induction of true somatic recombination involving homologous chromosomes. Analysis of the quadriradials from Muntjac cells indicates a non-random distribution with respect to the chromosomes involved and with respect to the points of conjunction. Sister chromatid exchange and quadriradial formation may reflect the outcome of repair processes involving a high frequency of homologous exchanges in the interphase nucleus.

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