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Case Reports
. 1998 Aug;33(2):129-35.
doi: 10.1046/j.1365-2559.1998.00463.x.

Differentiation of desquamative interstitial pneumonia (DIP) from pulmonary adenocarcinoma by immunocytochemistry

A E Mutton  1 , P S Hasleton, A Curry, P W Bishop, J Egan, K B Carroll, S Hanley
Affiliations
Case Reports

Differentiation of desquamative interstitial pneumonia (DIP) from pulmonary adenocarcinoma by immunocytochemistry

A E Mutton et al. Histopathology. 1998 Aug.

Abstract

Aim: After a misdiagnosis of pulmonary adenocarcinoma as desquamative interstitial pneumonia (DIP), we investigated whether immunohistochemical markers could differentiate these conditions.

Methods and results: Three cases of DIP and one pulmonary adenocarcinoma masquerading as DIP were studied by light and electron microscopy. All cases were mucin-negative. The cases of DIP were CD68 positive but cytokeratin-negative. The adenocarcinoma was cytokeratin-positive (AE1/3 and CAM5.2), as well as showing some CD68-positive cells. Markers for carcinoma (CEA, Ber-EP4, and Leu M1) were negative in all cases. Ultrastructurally the adenocarcinoma appeared to be derived from Type II pneumocytes.

Conclusion: Before a diagnosis of DIP is made, cytokeratin markers should be used.

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