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. 1976 Oct 15;32(10):1238-40.
doi: 10.1007/BF01953069.

Metabolism of 1,3,7-trimethyldihydrouric acid in the rat: new metabolic pathway of caffeine

M J Arnaud

Metabolism of 1,3,7-trimethyldihydrouric acid in the rat: new metabolic pathway of caffeine

M J Arnaud. Experientia. .

Abstract

[1-CH3-14C] 1,3,7-trimethyldihydrouric acid which, in quantity, is the most important caffeine metabolite, was isolated and purified from the urine of rats fed with [1-CH3-14C] caffeine. The oral administration of this metabolite to rats showed that 1,3,7-trimethyldihydrouric acid was excreted unchanged in urine and was therefore an end product of caffeine metabolism. This result implies a new metabolic pathway of caffeine.

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References

    1. Toxicol Appl Pharmacol. 1972 Dec;23(4):720-30 - PubMed
    1. Experientia. 1973 Aug 15;29(8):953-5 - PubMed