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. 1998 Nov;72(11):9337-44.
doi: 10.1128/JVI.72.11.9337-9344.1998.

Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro

Y J Zhang  1 , T Dragic, Y Cao, L Kostrikis, D S Kwon, D R Littman, V N KewalRamani, J P Moore
Affiliations

Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro

Y J Zhang et al. J Virol. 1998 Nov.

Abstract

We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium-inducing isolates could utilize only CCR5. All syncytium-inducing viruses used CXCR4, some also employed V28, and one (DH123) used CCR8 and APJ as well. A longitudinal series of HIV-1 subtype B isolates from an infected infant and its mother utilized Bonzo efficiently, as well as CCR5. The maternal isolates, which were syncytium inducing, also used CXCR4, CCR8, V28, and APJ.

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Figures

FIG. 1
FIG. 1
Use of CCR5 and Bonzo by HIV-1 isolates from a mother and her child. The replication of two isolates (m1 and m18) from infant P6 and of two isolates (m1b and m4b) from his mother (M6) in GHOST cells expressing CCR5 (a) or Bonzo (b) is indicated by the amount of p24 antigen production at 3 days (shaded bars) and 6 days (black bars) postinfection. Infant isolates P4 and P9 are also shown for comparison (see Tables 2 and 3). (c) Replication of different inocula of the last-obtained isolate (m36) from infant P6 in GHOST cells expressing CCR5 (shaded bars) or Bonzo (black bars), as determined by p24 antigen production 4 days postinfection.
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