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. 1976 Oct;5(5):379-88.
doi: 10.1016/0303-7207(76)90020-4.

Ovarian-independent fluctuations of estradiol receptor levels in mammalian tissues

A Hughes, H I Jacobson, R K Wagner, P W Jungblut

Ovarian-independent fluctuations of estradiol receptor levels in mammalian tissues

A Hughes et al. Mol Cell Endocrinol. 1976 Oct.

Abstract

Three types of periodic fluctuation in tissue concentrations of estradiol receptor protein have been observed. A seasonal variation is described in the uteri of 12-16-week-old calves and of ovariectomized pigs, and in mammary tumor tissue obtained from postmenopausal women. A circadian rhythm has been demonstrated in uteri of ovariectomized rats. An irregular periodic fluctuation has been found in uteri of ovariectomized and of ovariectomized/hypophysectomized rats, with the period varying from 9 to 15 days. These observations establish that a substantial turnover of receptor occurs in the absence of hormone and that 'normal' baseline values of receptor concentration do not exist.

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