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. 1998 Aug;139(2):285-6.
doi: 10.1046/j.1365-2133.1998.02367.x.

Long-term outcome of severe chronic plaque psoriasis following treatment with high-dose topical calcipotriol

T O Bleiker  1 , J F Bourke, R Mumford, P E Hutchinson
Affiliations

Long-term outcome of severe chronic plaque psoriasis following treatment with high-dose topical calcipotriol

T O Bleiker et al. Br J Dermatol. 1998 Aug.

Abstract

We have previously reported the effectiveness of high-dose calcipotriol in extensive psoriasis. We now report the long-term outcome in patients following this treatment. Twenty-eight patients with severe psoriasis were treated as in-patients with high-dose topical calcipotriol for 2 weeks. There was a mean reduction in the psoriasis area and severity index of 65%. Sixty-nine per cent were controlled for 3 months and 42% for 6 months. The relapse rate was comparable with that following Ingram's regimen, the in-patient stay was shorter and the treatment more acceptable. Careful monitoring of calcium homeostasis is mandatory.

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