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. 1998 Sep;9(3):413-21.
doi: 10.1016/s1074-7613(00)80624-x.

The pathway for processing leader-derived peptides that regulate the maturation and expression of Qa-1b

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Free article

The pathway for processing leader-derived peptides that regulate the maturation and expression of Qa-1b

A Bai et al. Immunity. 1998 Sep.
Free article

Abstract

Qa-1b and its human homolog, HLA-E, predominantly bind leader peptides derived from other class I molecules. Their presentation is TAP-dependent and proteasome-independent. We demonstrate that Dd targeted to the cytosol does not generate the Qa-1b peptide epitope even in the presence of lactacystin. Cells expressing herpes virus ICP-47 block the generation of this epitope, demonstrating that TAP functions in the transport of the peptide from cytosol to ER. This reveals a pathway for antigen presentation of leader peptides that involves translocation of a protein to the ER where its leader is cleaved followed by its release into the cytosol and transport back into the ER. Further, it ensures that Qa-1b expression mirrors the normal expression of class Ia molecules.

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