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Clinical Trial
. 1998 Nov;21(11):1540-2.
doi: 10.1002/(sici)1097-4598(199811)21:11<1540::aid-mus27>3.0.co;2-2.

Intrasphincteric injection of botulinum toxin is effective in long-term treatment of esophageal achalasia

V Annese  1 , M Basciani, O Borrelli, G Leandro, P Simone, A Andriulli
Affiliations
Clinical Trial

Intrasphincteric injection of botulinum toxin is effective in long-term treatment of esophageal achalasia

V Annese et al. Muscle Nerve. 1998 Nov.

Abstract

We investigated the long-term efficacy and safety of intrasphincteric injections of botulinum toxin (100 U) in 57 patients with esophageal achalasia. One month after treatment, 50 patients had improved (88%); both symptom score and LES pressure were significantly reduced (P < 0.001). After a mean follow-up of 24+/-15 months (range 6-48), 43 patients (75%) are still in remission, although repeat injections of toxin were needed to achieve a stable effect on symptoms.

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