doi: 10.1038/2661.
Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy
Affiliations
- PMID: 9771750
- DOI: 10.1038/2661
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Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy
Nat Med.
1998 Oct.
Erratum in
- Nat Med 1999 May;5(5):590
Abstract
Temporal lobe epilepsy is the most prevalent seizure disorder in adults. Compromised inhibitory neurotransmitter function in the hippocampus contributes to the hyperexcitability generating this condition, but the underlying molecular mechanisms are unknown. Combining patch-clamp recording and single-cell mRNA amplification (aRNA) techniques in single dentate granule cells, we demonstrate that expression of GABA(A) receptor subunit mRNAs is substantially altered in neurons from epileptic rats. These changes in gene expression precede epilepsy onset by weeks and correlate with profound alterations in receptor function, indicating that aberrant GABA(A) receptor expression and function has an essential role in the process of epileptogenesis.
Comment in
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GABA synapses enter the molecular big time.Nat Med. 1998 Oct;4(10):1115-6. doi: 10.1038/2608. Nat Med. 1998. PMID: 9771735 No abstract available.
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