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. 1998 Oct 15;17(20):6069-75.
doi: 10.1093/emboj/17.20.6069.

The Escherichia coli OxyS regulatory RNA represses fhlA translation by blocking ribosome binding

S Altuvia  1 , A Zhang, L Argaman, A Tiwari, G Storz
Affiliations

The Escherichia coli OxyS regulatory RNA represses fhlA translation by blocking ribosome binding

S Altuvia et al. EMBO J. .

Abstract

OxyS is a small untranslated RNA which is induced in response to oxidative stress in Escherichia coli. This novel RNA acts as a global regulator to activate or repress the expression of as many as 40 genes, including the fhlA-encoded transcriptional activator and the rpoS-encoded sigma(s) subunit of RNA polymerase. Deletion analysis of OxyS showed that different domains of the small RNA are required for the regulation of fhlA and rpoS. We examined the mechanism of OxyS repression of fhlA and found that the OxyS RNA inhibits fhlA translation by pairing with a short sequence overlapping the Shine-Dalgarno sequence, thereby blocking ribosome binding/translation.

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References

    1. Gene. 1987;53(1):85-96 - PubMed
    1. Mol Gen Genet. 1976 Apr 23;145(1):101-8 - PubMed
    1. J Bacteriol. 1989 May;171(5):2563-72 - PubMed
    1. J Biol Chem. 1989 Oct 25;264(30):17961-70 - PubMed
    1. J Mol Biol. 1989 Nov 20;210(2):265-80 - PubMed

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