Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1998 Nov;36(11):3435-7.
doi: 10.1128/JCM.36.11.3435-3437.1998.

Helicobacter pylori cagA status and s and m alleles of vacA in isolates from individuals with a variety of H. pylori-associated gastric diseases

D G Evans  1 , D M Queiroz, E N Mendes, D J Evans Jr
Affiliations
Comparative Study

Helicobacter pylori cagA status and s and m alleles of vacA in isolates from individuals with a variety of H. pylori-associated gastric diseases

D G Evans et al. J Clin Microbiol. 1998 Nov.

Abstract

The cagA gene was detected in 100% of 16 Helicobacter pylori isolates from patients with gastric carcinoma versus 78% of 18 isolates from patients with duodenal ulcers (P = 0.344) and only 64% of 22 isolates from patients with gastritis only (P = 0.005) in Brazil. Also, there was a significant association between isolation of cagA+ s1-type vacA H. pylori in cases of stomach cancer and ulcers as opposed to cases of gastritis only (P = 0.004), but this was not true in Houston (P = 0.238), where 94% of all isolates were cagA+.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Atherton J C, Cao P, Peek R M, Jr, Tummuru M K R, Blaser M J, Cover T L. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. J Biol Chem. 1995;270:17771–17777. - PubMed
    1. Atherton J C, Peek R M, Jr, Tham K T, Cover T L, Blaser M J. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology. 1997;112:92–99. - PubMed
    1. Blaser, M. J. 1994. Helicobacter pylori phenotypes associated with peptic ulceration. Scand. J. Gastroenterol. 29(Suppl. 205):1–5. - PubMed
    1. Blaser M J, Perez-Perez G I, Kleanthous H, Cover T L, Peek R M, Chyou P H, Stemmermann G N, Nomura A. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 1995;55:2111–2115. - PubMed
    1. Bukanov N O, Berg D E. Ordered cosmid library and high-resolution physical genetic map of Helicobacter pylori strain NCTC 11638. Mol Microbiol. 1994;11:509–523. - PubMed

Publication types

MeSH terms