Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Oct;18(5):497-507.
doi: 10.1023/a:1026327309345.

Interferon yield and MHC antigen expression of human medulloblastoma cells and its suppression during dibutyryl cyclic AMP-induced differentiation: do medulloblastoma cells derive from bipotent neuronal and glial progenitors?

K C Park  1 , K Shimizu, T Hayakawa
Affiliations

Interferon yield and MHC antigen expression of human medulloblastoma cells and its suppression during dibutyryl cyclic AMP-induced differentiation: do medulloblastoma cells derive from bipotent neuronal and glial progenitors?

K C Park et al. Cell Mol Neurobiol. 1998 Oct.

Abstract

1. Human medulloblastoma (ONS-76), a central nervous system (CNS)-derived undifferentiated cell line, was found to possess glial characteristics as defined by responses in the interferon (IFN) system; ONS-76 cells produced as much IFN-beta as human fibroblast and glioma cells by viral infection and poly(I):poly(C) induction. 2. Major histocompatibility complex (MHC) class I antigens were also induced under IFN-beta stimulation. ONS-76 cells expressed neurofilament protein, as shown by Northern blot analysis, and morphological differentiation was induced by dibutyryl cyclic AMP (dcAMP). 3. Expression of IFN-beta and MHC class I antigens was suppressed in ONS-76 cells during the dcAMP-induced differentiation. 4. These results showed that ONS-76 cells possessed a glial property in IFN system responses and a neuronal property in cytoskeleton protein, suggesting that the precursors of medulloblastoma may be characterized as bipotent neuronal and glial progenitors in CNS.

PubMed Disclaimer

References

    1. Bailey, P., and Cushing, H. (1925). Medulloblastoma cerebelli; A common type of midcerebellar glioma of childhood. Arch. Neurol. Psychiat.14:192–224.
    1. Barlow, D. C., Randle, C. F., and Burke, D. C. (1984). Interferon synthesis in the early post-implantation mouse embryo. Differentiation27:229–235. - PubMed
    1. Cathala, F., and Baron, S. (1970). Interferon in rabbit brain, cerebrospinal fluid and serum following administration of polyinosinic-polycytidylic acid. J. Virol.14:1355–1358. - PubMed
    1. Chader, G. J. (1987). Multipotential differentiation of human Y-19 retinoblastoma cells in attachment culture. Cell Different. 20:209–216. - DOI - PubMed
    1. Church, G. M., and Gilbert, W. (1984). Genomic sequencing. Proc. Natl. Acad. Sci. USA81:1991–1995. - PMC - PubMed

Publication types

MeSH terms