Xanthogranulomatous cystitis associated with malignant neoplasms of the bladder

Abstract

Aims: Two cases of xanthogranulomatous cystitis in conjunction with malignant neoplasms of the bladder are described.

Methods and results: A partial cystectomy [corrected] specimen from a 55-year-old man showed a urachal adenocarcinoma partly surrounded by a large xanthogranulomatous inflammatory mass. Multiple resections of the locally recurring tumour over the subsequent 10 years did not show further xanthogranulomatous changes. In the second case, a 76-year-old woman, a focus of xanthogranulomatous cystitis was present near a moderately differentiated transitional-cell carcinoma of the vesico-ureteric junction.

Conclusions: Xanthogranulomatous inflammation is associated with malignant neoplasms in the bladder as it is in the kidney and extra-urinary sites, as well as with benign neoplasms and non-neoplastic conditions such as urachal diverticula. The presence of a concomitant neoplasm should therefore be considered when the diagnosis of xanthogranulomatous cystitis is made.