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Review
. 1998 Oct;153(4):1023-33.
doi: 10.1016/s0002-9440(10)65647-7.

Risk factors and progression of atherosclerosis in youth. PDAY Research Group. Pathological Determinants of Atherosclerosis in Youth

R W Wissler  1 , J P Strong
Affiliations
Review

Risk factors and progression of atherosclerosis in youth. PDAY Research Group. Pathological Determinants of Atherosclerosis in Youth

R W Wissler et al. Am J Pathol. 1998 Oct.
No abstract available

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Figures

Figure 1.
Figure 1.
Bar graphs showing percent of intimal surface area involved with fatty streaks and raised lesions for both the thoracic and the lower abdominal aortas as well as the right coronary artery. The effects of age (by five-year groups), sex, and race are shown. (Reprinted from PDAY Research Group. Arterioscler Thromb 1993, 13:1291–1298, with permission).
Figure 2.
Figure 2.
Bar graphs showing percentage of intimal surface area involved with lesions by panniculus thickness, adjusted for sex, race, and age. Top: fatty streaks; Bottom: raised lesions. (Adapted from Arterioscler Thromb Vasc Biol 1995, 15:431–440, with permission.)
Figure 3.
Figure 3.
Quantitative analyses of collagen and esterified cholesterol in square centimeters of the standardized dorsal and ventral samples of the thoracic and lower abdominal aortas plotted by age groups. The height of the bars indicates geometric means and the ninety-five percent confidence intervals are also indicated. (Reprinted from Matrix 1993, 13:294, with permission.)
Figure 4.
Figure 4.
Bar graphs showing percentage of intimal surface area involved with lesions by age and blood pressure group, adjusted for race (males only). (Adapted from Arterioscler Thromb Vasc Biol 1995, 15:2222–2228, with permission.)
Figure 5.
Figure 5.
A: Observed microscopic classifications of the 55 cases with the highest postmortem serum thiocyanate levels (solid black bars) as compared to the 50 cases with the lowest postmortem serum thiocyanate levels in the 500 cases for which these analyses were available in this study. (Reprinted from Chapter 27 in Atherosclerosis and Coronary Artery Disease, 1995, Lippincott-Raven, with permission). B: Bar graphs showing the quantitative analyses on the 75 cases with the high extremes of the renal indices for hypertension as compared to the 75 cases with the lowest renal indices from this total group of 750 PDAY cases on which these renal indices were available at the time of this study. Negatives indicate that no microscopic lesions were seen. FS1 is a fatty streak in which most of the lipid is intracellular and in FS2, it is mostly extracellular. The FP numbers 1–4 correspond to the four types of intermediate (fatty plaque) lesions and the term “fibrous” refers to the typical fibrous plaque with a fibrous cap and a fat-filled necrotic center. “Missing” means that a few microscopic sections were not available.
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References

    1. Wissler RW: The value of the autopsy for understanding cardiovascular disease. Arch Pathol Lab Med 1984, 108:479-483 - PubMed
    1. Wissler RW: The problems of procedures for the study of the pathological processes of human atherosclerosis. Glagov S Newman WP, III Schaffer SA eds. Pathobiology of the Human Atherosclerotic Plaque. 1990, :pp 263-270 Springer Verlag, New York
    1. Wissler RW, Vesselinovitch D, Komatsu A: The contribution of studies of atherosclerotic lesions in young people to future research. Ann NY Acad Sci 1990, 598:418-434 - PubMed
    1. Wissler RW: Morphological characteristics of the developing atherosclerotic plaque: Animal studies and studies of lesions from young people. Weber PC Leaf A eds. Atherosclerosis: Its Pathogenesis and the Role of Cholesterol. 1991, :pp 91-103 Raven Press, New York
    1. Wissler RW: USA multicenter study of the pathobiology of atherosclerosis in youth. Ann NY Acad Sci 1991, 623:26-39 - PubMed

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