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Review
. 1998 Oct;51(4):1172-5.
doi: 10.1212/wnl.51.4.1172.

Lamotrigine-associated anticonvulsant hypersensitivity syndrome

R G Schlienger  1 , S R Knowles, N H Shear
Affiliations
Review

Lamotrigine-associated anticonvulsant hypersensitivity syndrome

R G Schlienger et al. Neurology. 1998 Oct.

Abstract

We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions consistent with the features of the anticonvulsant hypersensitivity syndrome (AHS) to identify characteristics of the syndrome. We identified 26 cases (mean age, 28+/-18 years; range, 3.5 to 74 years; 54% female), of which nine were published. The characteristics of the syndrome associated with lamotrigine are comparable to AHS induced by older aromatic anticonvulsants.

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