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. 1998:440:77-80.
doi: 10.1007/978-1-4615-5331-1_10.

Differential receptor-functionality of the two distinct receptor proteins for mouse hepatitis virus

N Ohtsuka  1 , Y K Yamada, K Saeki, F Taguchi
Affiliations

Differential receptor-functionality of the two distinct receptor proteins for mouse hepatitis virus

N Ohtsuka et al. Adv Exp Med Biol. 1998.

Abstract

We compared the virus-binding activity and receptor-functionality of the receptor proteins isolated from mouse hepatitis virus (MHV)-susceptible BALB/c mice (MHVR1) and MHV-resistant SJL mice (MHVR2). By using a soluble receptor protein which lacked the transmembrane and intracytoplasmic domains, virus overlay protein blot assay and neutralization tests showed that MHVR1 bound to JHM cl-2 virus with 300-500 times higher efficiency than to MHVR2. MHVR1 was revealed to have 10-30 fold higher receptor-functionality than MHVR2 when examined by measuring virus-binding to the receptor expressed on the cell surface. These findings suggested that the differences in susceptibility between BALB/c and SJL mice may depend upon the genotype of the MHV receptor.

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