doi: 10.1038/2321.
The burst phase in ribonuclease A folding and solvent dependence of the unfolded state
Affiliations
- PMID: 9783747
- DOI: 10.1038/2321
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The burst phase in ribonuclease A folding and solvent dependence of the unfolded state
Nat Struct Biol.
1998 Oct.
Abstract
Submillisecond burst phase signals measured in kinetic protein folding experiments have been widely interpreted in terms of the fast formation of productive folding intermediates. Experimental comparisons with non-folding polypeptide chains show that, for ribonuclease A and cytochrome c, these signals in fact reflect a shift from one biased ensemble of the unfolded state to another as a function of change in denaturant concentration.
Comment in
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Speeding along the protein folding highway, are we reading the signs correctly?Nat Struct Biol. 1998 Oct;5(10):846-8. doi: 10.1038/2286. Nat Struct Biol. 1998. PMID: 9783738 No abstract available.