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. 1998 Oct;61(10):1302-3.
doi: 10.1021/np980129a.

Debromosceptrin, an alkaloid from the Caribbean sponge Agelas conifera

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Debromosceptrin, an alkaloid from the Caribbean sponge Agelas conifera

X Shen et al. J Nat Prod. 1998 Oct.

Abstract

As the result of a structurally guided isolation to identify lead compounds for the treatment of opportunistic infections of AIDS, the dihydrochloride salt of a new symmetrical pyrrole dimer debromosceptrin (1), and two known pyrrole analogues (2 and 3) were isolated from the Caribbean sponge Agelas coniferacollected from Belize. The structure of debromosceptrin was identified by analysis of spectral data. 15N spectral data assignments were made for compounds 1-3. Compounds 2 and 3 showed marginal inhibition of Mycobacterium tuberculosis.

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