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. 1978 Jul 14;28(1):13-20.
doi: 10.1007/BF02889052.

Ultrastructural changes in beta-cells of pancreatic islets in alpha-amanitin-poisoned mice

M Derenzini, C M Betts, C Busi, L Fiume

Ultrastructural changes in beta-cells of pancreatic islets in alpha-amanitin-poisoned mice

M Derenzini et al. Virchows Arch B Cell Pathol. .

Abstract

In mice poisoned by alpha-amanitin nuclear changes typical of this toxin were observed in beta-cells of pancreatic islets. The lesions became progressively more severe and at 48 h after toxin injection some cells were necrotic. The damage to these cells could have implications in the changes in glycogen metabolism which occur after alpha-aminitin poisoning.

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