doi: 10.1007/BF02889052.
Ultrastructural changes in beta-cells of pancreatic islets in alpha-amanitin-poisoned mice
- PMID: 97854
- DOI: 10.1007/BF02889052
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Ultrastructural changes in beta-cells of pancreatic islets in alpha-amanitin-poisoned mice
Virchows Arch B Cell Pathol.
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Abstract
In mice poisoned by alpha-amanitin nuclear changes typical of this toxin were observed in beta-cells of pancreatic islets. The lesions became progressively more severe and at 48 h after toxin injection some cells were necrotic. The damage to these cells could have implications in the changes in glycogen metabolism which occur after alpha-aminitin poisoning.
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