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Review
. 1998 Jun-Aug;92(3-4):221-4.
doi: 10.1016/s0928-4257(98)80014-4.

The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594

M W Decker  1 , P Curzon, M W Holladay, A L Nikkel, R S Bitner, A W Bannon, D L Donnelly-Roberts, P S Puttfarcken, T A Kuntzweiler, C A Briggs, M Williams, S P Arneric
Affiliations
Review

The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594

M W Decker et al. J Physiol Paris. 1998 Jun-Aug.

Abstract

ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic ABT-594. However, lidocaine-inactivation of the NRM prevents the antinociceptive effect of systemic (-)-nicotine but not that of systemic ABT-594.

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