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Review
. 1998 Jun-Aug;92(3-4):279-81.
doi: 10.1016/s0928-4257(98)80033-8.

Role of neurotrophic factors in motoneuron development

C E Henderson  1 , Y Yamamoto, J Livet, V Arce, A Garces, O deLapeyrière
Affiliations
Review

Role of neurotrophic factors in motoneuron development

C E Henderson et al. J Physiol Paris. 1998 Jun-Aug.

Abstract

More than 10 factors from different gene families are now known to enhance motoneuron survival, and to be expressed in a manner consistent with a role in regulating motoneuron numbers during development. We provide evidence that: a) different factors may act on different sub-populations of motoneurons; b) different factors may act in synergy on a given motoneuron. Thus, the functional diversity of motoneurons, and the cellular complexity of their environment, may be reflected in the mechanisms that have evolved to keep them alive.

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