Review
doi: 10.1016/s0959-437x(98)80016-6.
Hypoxia-inducible factor 1: master regulator of O2 homeostasis
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- PMID: 9794818
- DOI: 10.1016/s0959-437x(98)80016-6
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Review
Hypoxia-inducible factor 1: master regulator of O2 homeostasis
Curr Opin Genet Dev.
1998 Oct.
Free article
Abstract
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.
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