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Review
. 1998 Oct;8(5):588-94.
doi: 10.1016/s0959-437x(98)80016-6.

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

G L Semenza  1
Affiliations
Free article
Review

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

G L Semenza. Curr Opin Genet Dev. 1998 Oct.
Free article

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.

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