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Review
. 1998 Oct;10(5):545-51.
doi: 10.1016/s0952-7915(98)80222-7.

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

M E Peter  1 , P H Krammer
Affiliations
Review

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

M E Peter et al. Curr Opin Immunol. 1998 Oct.

Abstract

This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CD95-mediated apoptotic process and how viral proteins interfere with crucial steps of this signaling pathway.

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