Review
doi: 10.1016/s0952-7915(98)80227-6.
How do cytotoxic lymphocytes kill their targets?
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- PMID: 9794837
- DOI: 10.1016/s0952-7915(98)80227-6
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Review
How do cytotoxic lymphocytes kill their targets?
Curr Opin Immunol.
1998 Oct.
Abstract
CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.
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