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Review
. 1998 Oct;10(5):581-7.
doi: 10.1016/s0952-7915(98)80227-6.

How do cytotoxic lymphocytes kill their targets?

S Shresta  1 , C T Pham, D A Thomas, T A Graubert, T J Ley
Affiliations
Review

How do cytotoxic lymphocytes kill their targets?

S Shresta et al. Curr Opin Immunol. 1998 Oct.

Abstract

CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.

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