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Review
. 1998 Oct;10(5):573-80.
doi: 10.1016/s0952-7915(98)80226-4.

Clinical applications of TNF-alpha in cancer

F J Lejeune  1 , C Rüegg, D Liénard
Affiliations
Review

Clinical applications of TNF-alpha in cancer

F J Lejeune et al. Curr Opin Immunol. 1998 Oct.

Abstract

High-dose TNF-alpha plus chemotherapy, with or without IFN-gamma, can be safely administered regionally through isolated limb perfusion. This procedure produced between 70% and 80% complete remission in cases of in transit melanoma metastases and between 25% and 36% complete remission in cases of inextirpable soft-tissue sarcomas. Dual targeting is involved; TNF-alpha and IFN-gamma induce apoptosis of angiogenic endothelium, while melphalan induces apoptosis of tumour cells.

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