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. 1998 Nov;42(11):3012-3.
doi: 10.1128/AAC.42.11.3012.

In vitro activity of a new polyene, SPA-S-843, against yeasts

C Rimaroli  1 , T Bruzzese
Affiliations

In vitro activity of a new polyene, SPA-S-843, against yeasts

C Rimaroli et al. Antimicrob Agents Chemother. 1998 Nov.

Abstract

The in vitro activity of a new water-soluble polyene, SPA-S-843, was evaluated against 116 strains of Candida, Cryptococcus, and Saccharomyces spp. and compared with that of amphotericin B. SPA-S-843 demonstrated better inhibitory activity against all of the yeasts examined and better fungicidal activity against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis than did amphotericin B.

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References

    1. Anaisse E J, Bodey G P, Rinaldi M G. Emerging fungal pathogens. Eur J Clin Microbiol Infect Dis. 1989;8:323–330. - PubMed
    1. Bonabello A, Bruzzese T. Abstracts of trends in invasive fungal infections 4, Barcelona, Spain. 1997. Antifungal activity of SPA-S-843, in comparison with amphotericin B and fluconazole, on murine experimental infections, abstr. P-89; p. 137.
    1. Cameron M L, Schell W A, Bruch S, Bartlett J A, Waskin H A, Perfect J R. Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms in individuals seropositive for human immunodeficiency virus type 1. Antimicrob Agents Chemother. 1993;37:2449–2453. - PMC - PubMed
    1. Fung-Tomc J C, Minassian B, Huczko E, Kolek B, Bonner D P, Kessler R E. In vitro antifungal and fungicidal spectra of a new pradimicin derivative, BMS-181184. Antimicrob Agents Chemother. 1995;39:295–300. - PMC - PubMed
    1. Galgiani J N, Lewis M L. In vitro studies of activities of the antifungal triazoles SCH56592 and itraconazole against Candida albicans, Cryptococcus neoformans, and other pathogenic yeasts. Antimicrob Agents Chemother. 1997;41:180–183. - PMC - PubMed

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