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Clinical Trial
. 1998 Jul;79(1):F61-3.
doi: 10.1136/fn.79.1.f61.

Nasal high frequency ventilation in neonates with moderate respiratory insufficiency

M van der Hoeven  1 , E Brouwer, C E Blanco
Affiliations
Clinical Trial

Nasal high frequency ventilation in neonates with moderate respiratory insufficiency

M van der Hoeven et al. Arch Dis Child Fetal Neonatal Ed. 1998 Jul.

Abstract

Aim: To investigate the efficacy of nasal high frequency ventilation (nHFV) in newborn infants with moderate respiratory insufficiency.

Method: Twenty one preterm and term neonates were treated with nHFV for respiratory insufficiency. Criteria for starting nHFV were: deterioration on nasal CPAP expressed by a median pH of 7.24 and pCO2 of 8.3 kPa, or increasing FIO2. nHFV was delivered using the Infant Star ventilator. Ventilator setting amplitude was 35 cm H2O; mean airway pressure 7 cm H2O; and frequency 10 Hz.

Results: pCO2 decreased significantly from 8.3 kPa to 7.2 kPa after nHFV was started. In five patients nHFV was discontinued after a median period of 6 1/2 hours due to CO2 retention and high oxygen need, and endotracheal mechanical ventilation was started.

Conclusions: nHFV can reduce pCO2 in neonates with moderate respiratory insufficiency and, therefore, could be used to decrease the need for endotracheal mechanical ventilation.

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References

    1. J Appl Physiol Respir Environ Exerc Physiol. 1984 Mar;56(3):553-63 - PubMed
    1. J Pediatr. 1983 May;102(5):764-8 - PubMed
    1. Arch Dis Child. 1987 Sep;62(9):882-8 - PubMed
    1. Arch Dis Child. 1983 Aug;58(8):612-5 - PubMed
    1. Acta Anaesthesiol Scand Suppl. 1989;90:170-1 - PubMed

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