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Clinical Trial
. 1998 Jul;91(7):483-8.
doi: 10.1093/qjmed/91.7.483.

Low-dose low-frequency imiglucerase as a starting regimen of enzyme replacement therapy for patients with type I Gaucher disease

D Elstein  1 , A Abrahamov, I Hadas-Halpern, A Meyer, A Zimran
Affiliations
Clinical Trial

Low-dose low-frequency imiglucerase as a starting regimen of enzyme replacement therapy for patients with type I Gaucher disease

D Elstein et al. QJM. 1998 Jul.

Abstract

The issue of the interplay of optimal dosage and frequency regimens for enzyme replacement therapy in type I Gaucher disease has been a source of controversy during the 7 years since the introduction of the placenta-derived enzymatic preparation in 1991. We present the results of treatment with the human recombinant form of the enzyme in 28 type I Gaucher patients, who have been treated for 6 to 24 months. As long as cost is an important factor in the management of patients with Gaucher disease, low-dose low-frequency imiglucerase promises satisfactory clinical improvement without compromising quality of life.

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