Comparative Study
The role of nm23 in melanoma progression and its prognostic significance
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- PMID: 9798412
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Comparative Study
The role of nm23 in melanoma progression and its prognostic significance
Pol J Pathol.
1998.
Abstract
The nm23 monoclonal antibody directed to specific antigen was applied for investigation of 29 benign naevi, 59 melanomas of different Clark level and locations, 4 lymph node and 28 organ metastases, using quantitative immunohistochemistry. The reduced expression of nm23 protein was associated with the tumor progression. A statistically significant difference (p = 0.0014) was found in nm23 protein expression between naevi and malignant melanomas. Additionally, a reduced protein level in metastases was found. A strong correlation was found between nm23 expression and survival of patients as well as the presence of metastasis (p = 0.0003).
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