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. 1998 Nov;5(6):894-6.
doi: 10.1128/CDLI.5.6.894-896.1998.

Aging and the immune response to tetanus toxoid: diminished frequency and level of cellular immune reactivity to antigenic stimulation

D Schatz  1 , T Ellis, E Ottendorfer, E Jodoin, D Barrett, M Atkinson
Affiliations

Aging and the immune response to tetanus toxoid: diminished frequency and level of cellular immune reactivity to antigenic stimulation

D Schatz et al. Clin Diagn Lab Immunol. 1998 Nov.

Abstract

The period of efficacious immune reactivity afforded by tetanus immunization and the need for continuing some forms of tetanus vaccination programs have been the subjects of recent debates. Our studies demonstrate that the level of antitetanus immunity based on immunological memory (i.e., cellular immune responsiveness) varies dramatically as a function of age, with older individuals constituting a population which is increasingly susceptible to tetanus infection.

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Figures

FIG. 1
FIG. 1
Age and the frequency of cellular immunity to tetanus. Bars indicate the percentage of individuals providing a positive SI within each age group.
See this image and copyright information in PMC

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