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. 1976;33(2):66-71.
doi: 10.1159/000225107.

Some examples of dose-response studies in chemical carcinogenesis

R Port, D Schmähl, J Wahrendorf

Some examples of dose-response studies in chemical carcinogenesis

R Port et al. Oncology. 1976.

Abstract

Three studies of DRUCKREY and his group, on diethylnitrosamine and 4-dimethylaminostilbene, are described. In a recent experiment, urethane was given chronically to rats and mice, at doses between 100 and 12,500 mug/kg/day. The results in rats were evaluated with the Mantel-Bryan procedure; risk estimates greatly differed, depending on the slope used for calculation.

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