Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1998 Sep 18;160(1):102-4.
doi: 10.1016/s0022-510x(98)00238-x.

Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome

C Kawanishi  1 , Y Shimoda, J Fujimaki, H Onishi, K Suzuki, T Hanihara, N Sugiyama, K Kosaka
Affiliations
Case Reports

Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome

C Kawanishi et al. J Neurol Sci. .

Abstract

Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous for a mutated CYP2D6J allele conferring a poor-metabolizer phenotype. Possession of this trait may contribute to susceptibility to NMS.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources